Immuno-Interface Score to Predict Outcome in Colorectal Cancer Independent of Microsatellite Instability Status.

ABSTRACT: Tumor-associated immune cells have been shown to predict patient outcome in colorectal (CRC) and other cancers. Spatial digital image analysis-based cell quantification increases the informative power delivered by tumor microenvironment features and leads to new prognostic scoring systems. In this study we evaluated the intratumoral density of immunohistochemically stained CD8, CD20 and CD68 cells in 87 cases of CRC (48 were microsatellite stable, MSS, and 39 had microsatellite instability, MSI) in both the intratumoral tumor tissue and within the tumor-stroma interface zone (IZ) which was extracted by a previously developed unbiased hexagonal grid analytics method. Indicators of immune-cell gradients across the extracted IZ were computed and explored along with absolute cell densities, cl

SUBMITTER: Nestarenkaite A 

PROVIDER: S-EPMC7600992 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature