Revisiting Traumatic Brain Injury: From Molecular Mechanisms to Therapeutic Interventions.

ABSTRACT: Studying the complex molecular mechanisms involved in traumatic brain injury (TBI) is crucial for developing new therapies for TBI. Current treatments for TBI are primarily focused on patient stabilization and symptom mitigation. However, the field lacks defined therapies to prevent cell death, oxidative stress, and inflammatory cascades which lead to chronic pathology. Little can be done to treat the mechanical damage that occurs during the primary insult of a TBI; however, secondary injury mechanisms, such as inflammation, blood-brain barrier (BBB) breakdown, edema formation, excitotoxicity, oxidative stress, and cell death, can be targeted by therapeutic interventions. Elucidating the many mechanisms underlying secondary injury and studying targets of neuroprotective therapeutic agents

SUBMITTER: Jarrahi A 

PROVIDER: S-EPMC7601301 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature