Limited Availability of General Co-Repressors Uncovered in an Overexpression Context during Wing Venation in Drosophila melanogaster.

ABSTRACT: Cell fate is determined by the coordinated activity of different pathways, including the conserved Notch pathway. Activation of Notch results in the transcription of Notch targets that are otherwise silenced by repressor complexes. In Drosophila, the repressor complex comprises the transcription factor Suppressor of Hairless (Su(H)) bound to the Notch antagonist Hairless (H) and the general co-repressors Groucho (Gro) and C-terminal binding protein (CtBP). The latter two are shared by different repressors from numerous pathways, raising the possibility that they are rate-limiting. We noted that the overexpression during wing development of H mutants H^dNT and H^LD compromised in Su(H)-binding induced ectopic veins. On the basis of the role of

SUBMITTER: Nagel AC 

PROVIDER: S-EPMC7601384 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature