Role of Protein Kinase CK2 in Aberrant Lipid Metabolism in Cancer.

ABSTRACT: Uncontrolled proliferation is a feature defining cancer and it is linked to the ability of cancer cells to effectively adapt their metabolic needs in response to a harsh tumor environment. Metabolic reprogramming is considered a hallmark of cancer and includes increased glucose uptake and processing, and increased glutamine utilization, but also the deregulation of lipid and cholesterol-associated signal transduction, as highlighted in recent years. In the first part of the review, we will i) provide an overview of the major types of lipids found in eukaryotic cells and their importance as mediators of intracellular signaling pathways ii) analyze the main metabolic changes occurring in cancer development and the role of oncogenic signaling in supporting aberrant lipid metabolism and iii) d

SUBMITTER: Guerra B 

PROVIDER: S-EPMC7601870 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature