Renal ¹²³I-MIBG Uptake before and after Live-Donor Kidney Transplantation.

ABSTRACT: Increased sympathetic activity is suggested to be part of the pathogenesis in several diseases. Methods to evaluate sympathetic activity and renal nervous denervation procedural success are lacking. Scintigraphy using the norepinephrine analog Iodine-123 Metaiodobenzylguanidine (¹²³I-MIBG) might provide information on renal sympathetic nervous activity. Renal transplantation induces complete denervation of the kidney and as such represents an ideal model to evaluate the renal ¹²³I-MIBG scintigraphy method. The aim of this study was to evaluate whether renal ¹²³I-MIBG scintigraphy can detect changes in renal sympathetic nervous activity following renal transplantation. Renal ¹²³I-MIBG scintigraphy was performed in eleven renal transplant recipient

SUBMITTER: Rasmussen T 

PROVIDER: S-EPMC7601882 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature