Proteostasis Disturbances and Inflammation in Neurodegenerative Diseases.

ABSTRACT: Protein homeostasis (proteostasis) disturbances and inflammation are evident in normal aging and some age-related neurodegenerative diseases. While the proteostasis network maintains the integrity of intracellular and extracellular functional proteins, inflammation is a biological response to harmful stimuli. Cellular stress conditions can cause protein damage, thus exacerbating protein misfolding and leading to an eventual overload of the degradation system. The regulation of proteostasis network is particularly important in postmitotic neurons due to their limited regenerative capacity. Therefore, maintaining balanced protein synthesis, handling unfolding, refolding, and degrading misfolded proteins are essential to preserve all cellular functions in the central nervous sysytem. Failing

SUBMITTER: Sonninen TM 

PROVIDER: S-EPMC7601929 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature