Porcine Circovirus Type 2 Pathogenicity Alters Host's Central Tolerance for Propagation.

ABSTRACT: Porcine circovirus type 2 (PCV2) infections and resulting diseases are a worldwide threat to pig production. PCV2 bears a uniqueness that allows for us to understand more about chronic infections and the immune system in general. The virus can be phylogenetically subdivided into PCV2a to PCV2h genotypes. Although vaccination against PCV2 has been seen to prevent the manifestation of PCV disease, PCV2 still lingers as subclinical infections in all developmental stages of pigs. The "slow and low" tactic gives PCV2 a particular advantage in a host's immune surveillance. Since the inception of the PCV2 associated panzootic, research scientists have been trying to understand the pathogenicity of PCV2. Different research groups found that one genotype group member was more pathogenic than others

SUBMITTER: Sidler X 

PROVIDER: S-EPMC7602090 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature