Development of prognosis model for colon cancer based on autophagy-related genes.

ABSTRACT:

Background

Autophagy is an orderly catabolic process for degrading and removing unnecessary or dysfunctional cellular components such as proteins and organelles. Although autophagy is known to play an important role in various types of cancer, the effects of autophagy-related genes (ARGs) on colon cancer have not been well studied.

Methods

Expression profiles from ARGs in 457 colon cancer patients were retrieved from the TCGA database ( https://portal.gdc.cancer.gov ). Differentially expressed ARGs and ARGs related to overall patient survival were identified. Cox proportional-hazard models were used to investigate the association between ARG expression profiles and patient prognosis.

Results

Twenty ARGs were significantly associated with the overall survival of colon

SUBMITTER: Wang X 

PROVIDER: S-EPMC7602324 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature