Autoregulation of JARID2 through PRC2 interaction with its antisense ncRNA.

ABSTRACT:

Objective

JARID2 is a member of chromatin-modifying Polycomb Repressive Complex-2 or PRC2. It plays a role in recruiting PRC2 to developmental genes and regulating its activity. JARID2 along with PRC2 is indispensable for normal development. However, it remains unclear how JARID2 expression itself is regulated. Recently a number of non-protein-coding RNAs or ncRNAs are shown to regulate transcription. An antisense ncRNA, JARID2-AS1, is expressed from the first intron of JARID2 isoform-1 but its role in regulation of JARID2 expression has not been investigated. The objective of this study was to explore the role of JARID2-AS1 in regulating JARID2 and consequently PRC2.

Results

We found that JARID2-AS1 is localised in the nucleus and shows anti-correlated expression pattern to

SUBMITTER: Al-Raawi D 

PROVIDER: S-EPMC7602346 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature