Differentially altered social dominance- and cooperative-like behaviors in Shank2- and Shank3-mutant mice.

ABSTRACT:

Background

Recent progress in genomics has contributed to the identification of a large number of autism spectrum disorder (ASD) risk genes, many of which encode synaptic proteins. Our understanding of ASDs has advanced rapidly, partly owing to the development of numerous animal models. Extensive characterizations using a variety of behavioral batteries that analyze social behaviors have shown that a subset of engineered mice that model mutations in genes encoding Shanks, a family of excitatory postsynaptic scaffolding proteins, exhibit autism-like behaviors. Although these behavioral assays have been useful in identifying deficits in simple social behaviors, alterations in complex social behaviors remain largely untested.

Methods

Two syndromic ASD mouse models-Shank2 consti

SUBMITTER: Han KA 

PROVIDER: S-EPMC7602353 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature