Relationship of amyloid beta and neurofibrillary tau deposition in Neurodegeneration in Aging Down Syndrome (NiAD) study at baseline.

ABSTRACT:

Importance

Adults with Down syndrome (DS) are at high-risk of revealing Alzheimer's disease (AD) pathology, in part due to the triplication of chromosome 21 encoding the amyloid precursor protein. Adults with DS are uniformly affected by AD pathology by their 30's and have a 70% to 80% chance of clinical dementia by their 60's. Our previous studies have assessed longitudinal changes in amyloid beta (Aβ) accumulation in DS.

Objective

The goal of the present study was to assess the presence of brain tau using [¹⁸F]AV-1451 positron emission tomography (PET) in DS and to assess the relationship of brain tau pathology to Aβ using Pittsburgh Compound B (PiB)-PET.

Design

Cohort study.

Setting

Multi-center study.

Participants

Participants consisted of

SUBMITTER: Tudorascu DL 

PROVIDER: S-EPMC7602678 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature