Treatment with Bifidobacteria can suppress Aβ accumulation and neuroinflammation in APP/PS1 mice.

ABSTRACT:

Background

Alzheimer's disease (AD), being a complex disorder, is affected either by genetic or environmental factors or both. It is observed that there is an excessive accumulation of amyloid β (Aβ) in the extracellular space of the brain. AD is the first neurodegenerative disease in the elderly, and so far there is no effective treatment. In recent years, many studies have reported that Alzheimer's disease has a relationship with gut microflora, indicating that regulating gut microbiota could offer therapeutic intervention for AD. This study explored the effect Bifidobacteria has in averting AD.

Methods

WT and APP/PS1 mice were used for the experiments. The mice were randomly assigned to four groups: WT group, WT + Bi group, AD group (APP/PS1 mouse) and AD + Bi grou

SUBMITTER: Wu Q 

PROVIDER: S-EPMC7602682 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature