Ionizing Irradiation Induces Vascular Damage in the Aorta of Wild-Type Mice.

ABSTRACT: There has been a recent upsurge of interest in the effects of ionizing radiation exposure on the circulatory system, because a mounting body of epidemiological evidence suggests that irradiation induces cardio- and cerebrovascular disease at a much lower dose and lower dose rate than previously considered. The goal of our project is to determine whether dose protraction alters radiation effects on the circulatory system in a mouse model. To this end, the use of wild-type mice is pivotal albeit without manifestation of vascular diseases, because disease models (e.g., apolipoprotein E-deficient mice) are prone to hormetic responses following protracted exposures. As such, here, we first set out to analyze prelesional changes in the descending thoracic aorta of wild-type mice up to six months

SUBMITTER: Hamada N 

PROVIDER: S-EPMC7603246 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature