White-matter functional topology: a neuromarker for classification and prediction in unmedicated depression.

ABSTRACT: Aberrant topological organization of brain connectomes underlies pathological mechanisms in major depressive disorder (MDD). However, accumulating evidence has only focused on functional organization in brain gray-matter, ignoring functional information in white-matter (WM) that has been confirmed to have reliable and stable topological organizations. The present study aimed to characterize the functional pattern disruptions of MDD from a new perspective-WM functional connectome topological organization. A case-control, cross-sectional resting-state functional magnetic resonance imaging study was conducted on both discovery [91 unmedicated MDD patients, and 225 healthy controls (HCs)], and replication samples (34 unmedicated MDD patients, and 25 HCs). The WM functional networks were constr

SUBMITTER: Li J 

PROVIDER: S-EPMC7603321 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature