Whole transcriptome analysis of adrenal glands from prenatal glucocorticoid programmed hypertensive rodents.

ABSTRACT: Prenatal glucocorticoid exposure is associated with the development of hypertension in adults. We have previously demonstrated that antenatal dexamethosone (DEX) administration in Wistar-Kyoto dams results in offspring with increased blood pressure coupled with elevated plasma epinephrine levels. In order to elucidate the molecular mechanisms responsible for prenatal DEX-mediated programming of hypertension, a whole-transcriptome analysis was performed on DEX programmed WKY male adrenal glands using the Rat Gene 2.0 microarray. Differential gene expression (DEG) analysis of DEX-exposed offspring compared with saline-treated controls revealed 142 significant DEGs (109 upregulated and 33 downregulated genes). DEG pathway enrichment analysis demonstrated that genes involved in circadian rhyth

SUBMITTER: Tharmalingam S 

PROVIDER: S-EPMC7603342 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature