CHA₂DS₂-VASc score, cerebral small vessel disease, and frailty in older patients with atrial fibrillation.

ABSTRACT: The CHA₂DS₂-VASc score is a validated predictor of ischemic stroke in atrial fibrillation (AF) patients. However, data are limited on whether the CHA₂DS₂-VASc score is associated with subclinical brain structural changes or physical frailty among older AF patients. We assessed the relationship between CHA₂DS₂-VASc scores and brain structural changes or physical frailty in AF patients without history of stroke. Overall, 117 patients completed a comprehensive geriatric assessment for physical frailty. In brain magnetic resonance imaging sub-study (n = 49), brain volume and white matter hyperintensity lesion burden were automatically quantified using the LESIONQUANT software program. Patients with high risk of CHA₂DS

SUBMITTER: Choi JY 

PROVIDER: S-EPMC7603394 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature