Activation of Liver X Receptor α Sensitizes Mice to T-Cell Mediated Hepatitis.

ABSTRACT: Autoimmune hepatitis (AIH) is an inflammatory disease of the liver. Liver X receptors (LXRs), including the α and β isoforms, are previously known for their anti-inflammatory activities. The goal of this study is to determine whether and how LXR plays a role in AIH. LXRα gain-of-function and loss-of-function mouse models were used, in conjunction with the concanavalin A (ConA) model of T-cell mediated hepatitis. We first showed that the hepatic expression of LXRα was decreased in the ConA model of hepatitis and in human patients with AIH. In the ConA model, we were surprised to find that activation of LXRα in the constitutively activated VP-LXRα whole-body knock-in (LXRα-KI) mice exacerbated ConA-induced AIH, whereas the LXRα^-/- mice showed attenuated ConA-induced

SUBMITTER: Gao L 

PROVIDER: S-EPMC7603537 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature