Effect of APOE ε4 genotype on amyloid-β and tau accumulation in Alzheimer's disease.

ABSTRACT:

Background

To assess the effects of apolipoprotein E (ApoE) ε4 genotype on amyloid-β (Aβ) and tau burden and their longitudinal changes in Alzheimer's disease (AD) spectrum.

Methods

Among 272 individuals who underwent PET scans (¹⁸F-florbetaben for Aβ and ¹⁸F-flortaucipir for tau) and ApoE genotyping, 187 individuals completed 2-year follow-up PET scans. After correcting for the partial volume effect, we compared the standardized uptake value ratio (SUVR) for Aβ and tau burden between the ε4+ and ε4- groups. By using a linear mixed-effect model, we measured changes in SUVR in the ApoE ε4+ and ε4- groups.

Results

The ε4+ group showed greater baseline Aβ burden in the diffuse cortical regions and greater tau burden in the lateral, and medial tempor

SUBMITTER: Baek MS 

PROVIDER: S-EPMC7603688 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature