Exosomal LncRNA-NEAT1 derived from MIF-treated mesenchymal stem cells protected against doxorubicin-induced cardiac senescence through sponging miR-221-3p.

ABSTRACT:

Background

The chemotherapy drug doxorubicin (Dox) is widely used for treating a variety of cancers. However, its high cardiotoxicity hampered its clinical use. Exosomes derived from stem cells showed a therapeutic effect against Dox-induced cardiomyopathy (DIC). Previous studies reported that exosomes derived from mesenchymal stem cells (MSCs) pretreated with macrophage migration inhibitory factor (MIF) (exosome^MIF) showed a cardioprotective effect through modulating long noncoding RNAs/microRNAs (lncRNAs/miRs). This study aimed to investigate the role of exosome^MIF in the treatment of DIC.

Results

Exosomes were isolated from control MSCs (exosome) and MIF-pretreated MSCs (exosome^MIF). Regulatory lncRNAs activated by MIF pretreatment were ex

SUBMITTER: Zhuang L 

PROVIDER: S-EPMC7603694 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature