Diagnostic value of serum HER2 levels in breast cancer: a systematic review and meta-analysis.

ABSTRACT:

Background

Measurement of serum human epidermal growth factor receptor-2 (HER-2/neu) levels might play an essential role as a diagnostic/screening marker for the early selection of therapeutic approaches and predict prognosis in breast cancer patients. We aimed to undertake a systematic review and meta-analysis focusing on the diagnostic/screening value of serum HER-2 levels in comparison to routine methods.

Methods

We performed a systematic search via PubMed, Scopus, Cochrane-Library, and Web of Science databases for human diagnostic studies reporting the levels of serum HER-2 in breast cancer patients, which was confirmed using the histopathological examination. Meta-analyses were carried out for sensitivity, specificity, accuracy, area under the ROC curve (AUC), positive

SUBMITTER: Shamshirian A 

PROVIDER: S-EPMC7603697 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature