Epigenome-wide DNA methylation and risk of breast cancer: a systematic review.

ABSTRACT:

Background

DNA methylation is a potential biomarker for early detection of breast cancer. However, robust evidence of a prospective relationship between DNA methylation patterns and breast cancer risk is still lacking. The objective of this study is to provide a systematic analysis of the findings of epigenome-wide DNA methylation studies on breast cancer risk, in light of their methodological strengths and weaknesses.

Methods

We searched major databases (MEDLINE, EMBASE, Web of Science, CENTRAL) from inception up to 30th June 2019, for observational or intervention studies investigating the association between epigenome-wide DNA methylation (using the HM450k or EPIC BeadChip), measured in any type of human sample, and breast cancer risk. A pre-established protocol was drawn

SUBMITTER: Ennour-Idrissi K 

PROVIDER: S-EPMC7603741 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature