Prognostic value of ¹⁸F-FDG PET and PET/CT for assessment of treatment response to neoadjuvant chemotherapy in breast cancer: a systematic review and meta-analysis.

ABSTRACT:

Background

We performed a systematic review and meta-analysis to evaluate the prognostic significance of ¹⁸F-FDG PET and PET/CT for evaluation of responses to neoadjuvant chemotherapy (NAC) in breast cancer patients.

Methods

We searched PubMed, Embase, and the Cochrane Library databases until June 2020 to identify studies that assessed the prognostic value of ¹⁸F-FDG PET scans during or after NAC with regard to overall (OS) and disease-free survival (DFS). Hazard ratios (HRs) and their 95% confidence intervals (CIs) were pooled meta-analytically using a random-effects model.

Results

Twenty-one studies consisting of 1630 patients were included in the qualitative synthesis. Twelve studies investigated the use of PET scans for interim response evalu

SUBMITTER: Han S 

PROVIDER: S-EPMC7603771 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature