A 14 immune-related gene signature predicts clinical outcomes of kidney renal clear cell carcinoma.

ABSTRACT: Kidney renal clear cell carcinoma (KIRC) is the leading cause of kidney cancer-related deaths. Currently, there are no studies in tumor immunology investigating the use of signatures as a predictor of overall survival in KIRC patients. Our study attempts to establish an immune-related gene risk signature to predict clinical outcomes in KIRC. A total of 528 patients from The Cancer Genome Atlas (TCGA) database were included in our analysis and randomly divided into training (n = 315) and testing sets (n = 213). We collected 1,534 immune-related genes from the Immunology Database and Analysis Portal as candidates to construct our signature. LASSO-COX was used to find gene models with the highest predictive ability. We used survival and Cox analysis to test the model's independe

SUBMITTER: Zou Y 

PROVIDER: S-EPMC7603789 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature