Fluorescence-guided hepatobiliary surgery with long and short wavelength fluorophores.

ABSTRACT:

Importance

Fluorescence-guided surgery (FGS) is a potentially powerful tool for hepatobiliary (HPB) surgery. The high sensitivity of fluorescence navigation is especially useful in settings where tactile feedback is limited.

Objective

The present narrative review evaluates literature on the use of FDA-approved fluorophores such as methylene blue (MB), 5-aminolevulinic acid (5-ALA), and indocyanine green (ICG) for clinical intra-operative image-guidance during HPB surgery.

Evidence review

Approaches such as dosing, timing, imaging devices and comparative endpoints are summarized. The feasibility and safety of fluorophores in visualizing the biliary tree, identify biliary leaks, outline anatomic hepatic segments, identify tumors, and evaluate perfusion and graft functio

SUBMITTER: Lwin TM 

PROVIDER: S-EPMC7603922 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature