Fetuin-A as a Potential Biomarker of Metabolic Variability Following 60 Days of Bed Rest.

ABSTRACT: Background: Fetuin-A is a hepatokine linked to the development of insulin resistance. The purpose of this study was to determine if 60 days head-down-tilt (HDT) bed rest increased circulating fetuin-A and if it was linked to whole body insulin sensitivity (IS). Additionally, we examined whether reactive jump training (RJT) could alleviate the metabolic changes associated with bed rest. Methods: 23 young men (29 ± 6 years, 181 ± 6 cm, 77 ± 7 kg) were randomized to a control (CTRL, n = 11) or RJT group (JUMP, n = 12) and exposed to 60 days of bed rest. Before and after bed rest, body composition and V . O 2 ⁢ p ⁢ e ⁢ a ⁢ k were measured and an oral glucose tolerance test was performed to estimate IS. Circulating lipids and fetuin-A were measured in fasting se

SUBMITTER: Ward K 

PROVIDER: S-EPMC7604312 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature