Oral Microbiome and Gingival Tissue Apoptosis and Autophagy Transcriptomics.

ABSTRACT: Objective: This study focused on documenting characteristics of the gingival transcriptome during various stages of periodontitis targeting genes associated with apoptotic and autophagic pathways and changes that specifically associate with features of the oral microbiome. Methods:Macaca mulatta (n = 18; 12-23 years) were examined at baseline and 0.5, 1, and 3 months of disease progression, as well as 5 months with clinical disease resolution. 16S sequencing and microarray analyses examined changes in the microbiome and gingival transcriptome, respectively, at each time point from every animal. Results: Specific patterns of apoptotic and autophagic genes were identified related to the initiation and progression of disease. The analysis also provided insig

SUBMITTER: Ebersole JL 

PROVIDER: S-EPMC7604357 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature