Spatial organization of functional clusters representing reward and movement information in the striatal direct and indirect pathways.

ABSTRACT: To obtain insights into striatal neural processes underlying reward-based learning and movement control, we examined spatial organizations of striatal neurons related to movement and reward-based learning. For this, we recorded the activity of direct- and indirect-pathway neurons (D1 and A2a receptor-expressing neurons, respectively) in mice engaged in probabilistic classical conditioning and open-field free exploration. We found broadly organized functional clusters of striatal neurons in the direct as well as indirect pathways for both movement- and reward-related variables. Functional clusters for different variables were partially overlapping in both pathways, but the overlap between outcome- and value-related functional clusters was greater in the indirect than direct pathway. Also, v

SUBMITTER: Shin JH 

PROVIDER: S-EPMC7604453 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature