Contractile pericytes determine the direction of blood flow at capillary junctions.

ABSTRACT: The essential function of the circulatory system is to continuously and efficiently supply the O₂ and nutrients necessary to meet the metabolic demands of every cell in the body, a function in which vast capillary networks play a key role. Capillary networks serve an additional important function in the central nervous system: acting as a sensory network, they detect neuronal activity in the form of elevated extracellular K⁺ and initiate a retrograde, propagating, hyperpolarizing signal that dilates upstream arterioles to rapidly increase local blood flow. Yet, little is known about how blood entering this network is distributed on a branch-to-branch basis to reach specific neurons in need. Here, we demonstrate that capillary-enwrapping projections of junctional, cont

SUBMITTER: Gonzales AL 

PROVIDER: S-EPMC7604512 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature