CXCL10 could drive longer duration of mechanical ventilation during COVID-19 ARDS.

ABSTRACT:

Background

COVID-19-related ARDS has unique features when compared with ARDS from other origins, suggesting a distinctive inflammatory pathogenesis. Data regarding the host response within the lung are sparse. The objective is to compare alveolar and systemic inflammation response patterns, mitochondrial alarmin release, and outcomes according to ARDS etiology (i.e., COVID-19 vs. non-COVID-19).

Methods

Bronchoalveolar lavage fluid and plasma were obtained from 7 control, 7 non-COVID-19 ARDS, and 14 COVID-19 ARDS patients. Clinical data, plasma, and epithelial lining fluid (ELF) concentrations of 45 inflammatory mediators and cell-free mitochondrial DNA were measured and compared.

Results

COVID-19 ARDS patients required mechanical ventilation (MV) for significantly lon

SUBMITTER: Blot M 

PROVIDER: S-EPMC7604548 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature