The long-term outcomes of CIS patients in the Barcelona inception cohort: Looking back to recognize aggressive MS.

ABSTRACT:

Objective

To explore the long-term outcomes of patients with clinically isolated syndromes from the Barcelona cohort.

Methods

We selected patients with a follow-up longer than 10 years to (1) estimate the risks of multiple sclerosis (MS) and disability accumulation according to the baseline number of T2 lesions and to compare treated versus untreated patients and early versus delayed treatment, and (2) to study baseline features of patients with aggressive MS (Expanded Disability Status Scale (EDSS) ⩾6.0 at 10 years).

Results

In all, 401 patients were included (mean follow-up of 14.4 (standard deviation of 2.9) years). A higher number of T2 lesions was associated with an earlier MS diagnosis and an earlier risk of irreversible disability. Early treatment was associate

SUBMITTER: Tintore M 

PROVIDER: S-EPMC7604549 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature