β-catenin signaling modulates the tempo of dendritic growth of adult-born hippocampal neurons.

ABSTRACT: In adult hippocampal neurogenesis, stem/progenitor cells generate dentate granule neurons that contribute to hippocampal plasticity. The establishment of a morphologically defined dendritic arbor is central to the functional integration of adult-born neurons. We investigated the role of canonical Wnt/β-catenin signaling in dendritogenesis of adult-born neurons. We show that canonical Wnt signaling follows a biphasic pattern, with high activity in stem/progenitor cells, attenuation in immature neurons, and reactivation during maturation, and demonstrate that this activity pattern is required for proper dendrite development. Increasing β-catenin signaling in maturing neurons of young adult mice transiently accelerated dendritic growth, but eventually produced dendritic defects and excessive

SUBMITTER: Heppt J 

PROVIDER: S-EPMC7604596 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature