Altered Brain Structural Networks in Patients with Brain Arteriovenous Malformations Located in Broca's Area.

ABSTRACT: Focal brain lesions, such as stroke and tumors, can lead to remote structural alterations across the whole-brain networks. Brain arteriovenous malformations (AVMs), usually presumed to be congenital, often result in tissue degeneration and functional displacement of the perifocal areas, but it remains unclear whether AVMs may produce long-range effects upon the whole-brain white matter organization. In this study, we used diffusion tensor imaging and graph theory methods to investigate the alterations of brain structural networks in 14 patients with AVMs in the presumed Broca's area, compared to 27 normal controls. Weighted brain structural networks were constructed based on deterministic tractography. We compared the topological properties and network connectivity between patients and nor

SUBMITTER: Li M 

PROVIDER: S-EPMC7604605 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature