Levodopa/Carbidopa Intestinal Gel Long-Term Outcome in Parkinson's Disease: Focus on Dyskinesia.

ABSTRACT:

Background

Levodopa-carbidopa intestinal gel (LCIG) treatment has shown variable effect on dyskinesia in Parkinson's disease (PD).

Objective

To identify PD patients who are likely to have troublesome dyskinesia under LCIG treatment and describe the pharmacokinetic-dynamic profile and dyskinesia phenomenology of those patients.

Methods

PD patients were assessed for clinical and therapeutic variables, before LCIG treatment (T0) and at last outpatient visit (T1). Sub-groups of patients with and without "troublesome dyskinesia" (UPDRS IV, item 33 ≥2), matched for disease and LCIG treatment duration, underwent a pharmacokinetic-dynamic assessment.

Results

We included 53 PD patients. After a mean of 51.7 ± 34.1 months of LCIG treatment, "off-time" was s

SUBMITTER: Fabbri M 

PROVIDER: S-EPMC7604637 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature