Hemiplegic Migraine in Glut1 Deficiency Syndrome and Paroxysmal Dyskinesia at Ketogenic Diet Induction: Case Report and Literature Review.

ABSTRACT:

Background

A rare symptom of Glut1 deficiency syndrome (Glut1 DS) is hemiplegic migraine (HM).

Case

We report a patient with Glut1 DS with a mild phenotype. His leading symptom was HM. As an unusual complication of the initiation of a ketogenic diet (KD), our patient developed paroxysmal nonkinesigenic dyskinesia. Paroxysmal dyskinesia occurred first and exclusively at the initiation of KD.

Literature review

There are a few case reports for HM in Glut1 DS. All patients had additional neurological symptoms. Regarding central nervous system symptoms such as paroxysmal dyskinesia triggered by KD, we found only 1 other case report.

Discussion

HM is part of the symptom complex of Glut1 DS and can be effectively treated by KD. Paroxysmal dyskinesia trigged by the ini

SUBMITTER: Gburek-Augustat J 

PROVIDER: S-EPMC7604676 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature