Primary Sjogren's Syndrome of Early and Late Onset: Distinct Clinical Phenotypes and Lymphoma Development.

ABSTRACT:

Objectives

To study the clinical, serological and histologic features of primary Sjögren's syndrome (pSS) patients with early (young ≤35 years) or late (old ≥65 years) onset and to explore the differential effect on lymphoma development.

Methods

From a multicentre study population of 1997 consecutive pSS patients, those with early or late disease onset, were matched and compared with pSS control patients of middle age onset. Data driven analysis was applied to identify the independent variables associated with lymphoma in both age groups.

Results

Young pSS patients (19%, n = 379) had higher frequency of salivary gland enlargement (SGE, lymphadenopathy, Raynaud's phenomenon, autoantibodies, C4 hypocomplementemia, hypergammaglobulinemia, leukopenia, and lymphoma (10.3%

SUBMITTER: Goules AV 

PROVIDER: S-EPMC7604905 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature