A systematic review of CXCL13 as a biomarker of disease and treatment response in rheumatoid arthritis.

ABSTRACT:

Background

The B cell chemoattractant CXCL13 is a promising biomarker in rheumatoid arthritis (RA), with a plausible role in supporting diagnosis, monitoring disease activity and as a prognostic value. It is a key chemokine driving the formation of lymphoid follicles within the inflamed synovium. The objective of this systematic review was to evaluate the role of CXCL13 as a viable biomarker in RA.

Methods

We conducted a systematic literature review of all published cohort and randomised controlled trials evaluating the role of CXCL13 in RA. The primary outcomes were; i) CXCL13 levels in RA patients compared to healthy controls, ii) the correlation between CXCL13 and markers of disease activity, and iii) the association between CXCL13 and treatment response.

Results

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SUBMITTER: Bechman K 

PROVIDER: S-EPMC7604968 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature