Association between miR-492 rs2289030 G>C and susceptibility to Hirschsprung disease in southern Chinese children.

ABSTRACT:

Objective

Hirschsprung disease (HSCR) originates from disruption of normal neural crest cell migration, differentiation, and proliferation during the fifth to eighth weeks of gestation. This results in the absence of intestinal ganglion cells in the distal intestinal tract. However, genetic variations affecting embryonic development of intestinal ganglion cells are unclear. Therefore, this study aimed to investigated the potential value of miR-492 rs2289030 G>C as a marker of susceptibility to HSCR.

Methods

In this case-control study in southern Chinese children, we collected samples from 1473 controls and 1470 patients with HSCR. TaqMan genotyping of miR-492 rs2289030 G>C was performed by real-time fluorescent quantitative polymerase chain reaction.

Results

SUBMITTER: Zheng Y 

PROVIDER: S-EPMC7604986 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature