Platelet Dysfunction and Thrombosis in JAK2^V617F-Mutated Primary Myelofibrotic Mice.

ABSTRACT:

Objective

The risk of thrombosis in myeloproliferative neoplasms, such as primary myelofibrosis varies depending on the type of key driving mutation (JAK2 [janus kinase 2], CALR [calreticulin], and MPL [myeloproliferative leukemia protein or thrombopoietin receptor]) and the accompanying mutations in other genes. In the current study, we sought to examine the propensity for thrombosis, as well as platelet activation properties in a mouse model of primary myelofibrosis induced by JAK2^V617F (janus kinase 2 with valine to phenylalanine substitution on codon 617) mutation. Approach and Results: Vav1-hJAK2^V617F transgenic mice show hallmarks of primary myelofibrosis, including significant megakaryocytosis and bone marrow fibrosis, with a moderate increase in red bl

SUBMITTER: Matsuura S 

PROVIDER: S-EPMC7605151 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature