Older, non-demented apolipoprotein ε₄ carrier males show hyperactivation and structural differences in odor memory regions: a blood-oxygen-level-dependent and structural magnetic resonance imaging study.

ABSTRACT: The current study sought to examine the interaction of sex and Apolipoprotein ε₄ status on olfactory recognition memory within non-demented, older individuals. We separated 39 participants into groups based on ε₄ status and sex. Each participant completed an olfactory memory recognition task during 2 functional magnetic resonance imaging scans and 1 structural scan. The ε₄ carriers had greater functional recruitment of memory regions during false positives relative to ε₄ non-carriers. During hits, the male ε₄ carriers showed greater functional recruitment compared to female ε₄ carriers. The ε₄ carriers had larger bilateral putamen volumes relative to ε₄ non-carriers. Neuroimaging data were significantly

SUBMITTER: Kapoulea EA 

PROVIDER: S-EPMC7605173 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature