Compliance Phenotypes in Early Acute Respiratory Distress Syndrome before the COVID-19 Pandemic.

ABSTRACT: Rationale: A novel model of phenotypes based on set thresholds of respiratory system compliance (Crs) was recently postulated in context of coronavirus disease (COVID-19) acute respiratory distress syndrome (ARDS). In particular, the dissociation between the degree of hypoxemia and Crs was characterized as a distinct ARDS phenotype.Objectives: To determine whether such Crs-based phenotypes existed among patients with ARDS before the COVID-19 pandemic and to closely examine the Crs-mortality relationship.Methods: We undertook a secondary analysis of patients with ARDS, who were invasively ventilated on controlled modes and enrolled in a large, multinational, epidemiological study. We assessed Crs, degree of hypoxemia, and associated Crs-based phenotypic patterns with th

SUBMITTER: Panwar R 

PROVIDER: S-EPMC7605177 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature