Impaired bone healing following treatment of established nonunion correlates with serum cytokine expression.

ABSTRACT: Delayed union and nonunion are a significant concern in long bone fractures and spinal fusions. Treatment of nonunion often entails multiple revision surgeries that further increase the financial, physical, and emotional burden on patients. The optimal treatment strategy for nonunions remains unclear in many cases, and the risk of complications after revision procedures remains high. This is in part due to our limited understanding of the biological mechanisms that inhibit proper bone healing and lead to nonunion. And yet, few preclinical models directly investigate how healing is impacted after establishment of nonunion, with most instead primarily focusing on treatment immediately after a fresh bone injury. Here, we utilized a critical size femoral defect model in rats where treatment wa

SUBMITTER: Cheng A 

PROVIDER: S-EPMC7605215 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature