A systems genetics approach reveals environment-dependent associations between SNPs, protein coexpression, and drought-related traits in maize.

ABSTRACT: The effect of drought on maize yield is of particular concern in the context of climate change and human population growth. However, the complexity of drought-response mechanisms makes the design of new drought-tolerant varieties a difficult task that would greatly benefit from a better understanding of the genotype-phenotype relationship. To provide novel insight into this relationship, we applied a systems genetics approach integrating high-throughput phenotypic, proteomic, and genomic data acquired from 254 maize hybrids grown under two watering conditions. Using association genetics and protein coexpression analysis, we detected more than 22,000 pQTLs across the two conditions and confidently identified 15 loci with potential pleiotropic effects on the proteome. We showed that even mil

SUBMITTER: Blein-Nicolas M 

PROVIDER: S-EPMC7605251 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature