Sex differences in human adipose tissue gene expression and genetic regulation involve adipogenesis.

ABSTRACT: Sex differences in adipose tissue distribution and function are associated with sex differences in cardiometabolic disease. While many studies have revealed sex differences in adipocyte cell signaling and physiology, there is a relative dearth of information regarding sex differences in transcript abundance and regulation. We investigated sex differences in subcutaneous adipose tissue transcriptional regulation using omic-scale data from ∼3000 geographically and ethnically diverse human samples. We identified 162 genes with robust sex differences in expression. Differentially expressed genes were implicated in oxidative phosphorylation and adipogenesis. We further determined that sex differences in gene expression levels could be related to sex differences in the genetics of gene expressio

SUBMITTER: Anderson WD 

PROVIDER: S-EPMC7605264 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature