Distinct contributions of DNA methylation and histone acetylation to the genomic occupancy of transcription factors.

ABSTRACT: Epigenetic modifications on chromatin play important roles in regulating gene expression. Although chromatin states are often governed by multilayered structure, how individual pathways contribute to gene expression remains poorly understood. For example, DNA methylation is known to regulate transcription factor binding but also to recruit methyl-CpG binding proteins that affect chromatin structure through the activity of histone deacetylase complexes (HDACs). Both of these mechanisms can potentially affect gene expression, but the importance of each, and whether these activities are integrated to achieve appropriate gene regulation, remains largely unknown. To address this important question, we measured gene expression, chromatin accessibility, and transcription factor occupancy in wild-

SUBMITTER: Cusack M 

PROVIDER: S-EPMC7605266 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature