A₃- and A₂B-nitrocorroles: synthesis and antiviral activity evaluation against human cytomegalovirus infection.

ABSTRACT: Human cytomegalovirus (hCMV) is responsible for several pathologies impacting immunocompromised patients and can trigger life-threatening infection. Several antivirals are available and are used in the clinic, but hCMV resistant strains have appeared and patients have encountered therapeutic failure. Hence, there is a constant need for new best in class or first in class antiviral molecules. We have previously shown that nitrocorroles could be used as a potent anti-hCMV agent without acute toxicity in mice. They therefore represent an excellent platform to perform structure-activity relationship (SAR) studies and to increase efficiency or reduce toxicity. We have generated original A₂B- and A₃-substituted nitrocorroles and have discovered optimized compounds with sele

SUBMITTER: Bucher L 

PROVIDER: S-EPMC7605276 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature