Hist-Immune signature: a prognostic factor in colorectal cancer using immunohistochemical slide image analysis.

ABSTRACT: Computerized image analysis for whole-slide images has been shown to improve efficiency, accuracy, and consistency in histopathology evaluations. We aimed to assess whether immunohistochemistry (IHC) image quantitative features can reflect the immune status and provide prognostic information for colorectal cancer patients. A fully automated pipeline was designed to extract histogram features from IHC digital images in a training set (N = 243). A Hist-Immune signature was generated with selected features using the LASSO Cox model. The results were validated using internal (N = 147) and external (N = 76) validation sets. The five-feature-based Hist-Immune signature was significantly associated with overall survival in training (HR 2.72, 95% CI 1.68-4.41, P < .001), internal (2.86, 1.2

SUBMITTER: Zhao K 

PROVIDER: S-EPMC7605350 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature