Validation of the BOADICEA model and a 313-variant polygenic risk score for breast cancer risk prediction in a Dutch prospective cohort.

ABSTRACT:

Purpose

We evaluated the performance of the recently extended Breast and Ovarian Analysis of Disease Incidence and Carrier Estimation Algorithm (BOADICEA version 5) in a Dutch prospective cohort, using a polygenic risk score (PRS) based on 313 breast cancer (BC)-associated variants (PRS₃₁₃) and other, nongenetic risk factors.

Methods

Since 1989, 6522 women without BC aged 45 or older of European descent have been included in the Rotterdam Study. The PRS₃₁₃ was calculated per 1 SD in controls from the Breast Cancer Association Consortium (BCAC). Cox regression analysis was performed to estimate the association between the PRS₃₁₃ and incident BC risk. Cumulative 10-year risks were calculated with BOADICEA including different sets of variables (

SUBMITTER: Lakeman IMM 

PROVIDER: S-EPMC7605432 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature