Retrospective in silico HLA predictions from COVID-19 patients reveal alleles associated with disease prognosis.

ABSTRACT:

Background

The Human Leukocyte Antigen (HLA) gene locus plays a fundamental role in human immunity, and it is established that certain HLA alleles are disease determinants.

Methods

By combining the predictive power of multiple in silico HLA predictors, we have previously identified prevalent HLA class I and class II alleles, including DPA1*02:02, in two small cohorts at the COVID-19 pandemic onset. Since then, newer and larger patient cohorts with controls and associated demographic and clinical data have been deposited in public repositories. Here, we report on HLA-I and HLA-II alleles, along with their associated risk significance in one such cohort of 126 patients, including COVID-19 positive (n=100) and negative patients (n=26).

Results

We recapitulate an enrichme

SUBMITTER: Warren RL 

PROVIDER: S-EPMC7605564 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature