The spatio-temporal landscape of lung pathology in SARS-CoV-2 infection.

ABSTRACT: Recent studies have provided insights into the pathology and immune response to coronavirus disease 2019 (COVID-19)^1-8. However thorough interrogation of the interplay between infected cells and the immune system at sites of infection is lacking. We use high parameter imaging mass cytometry⁹ targeting the expression of 36 proteins, to investigate at single cell resolution, the cellular composition and spatial architecture of human acute lung injury including SARS-CoV-2. This spatially resolved, single-cell data unravels the disordered structure of the infected and injured lung alongside the distribution of extensive immune infiltration. Neutrophil and macrophage infiltration are hallmarks of bacterial pneumonia and COVID-19, respectively. We provide evidence that SARS

SUBMITTER: Rendeiro AF 

PROVIDER: S-EPMC7605585 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature