Birth Characteristics and Risk of Early-Onset Synovial Sarcoma.

ABSTRACT:

Background

Synovial sarcoma is a rare cancer with peak incidence in the young adult period. Despite poor outcomes of this aggressive cancer, there is little epidemiologic research addressing its etiology.

Methods

We collected birth characteristic data on synovial sarcoma cases born during 1978-2015 and diagnosed during 1988-2015 in California (n = 244), and 12,200 controls frequency-matched on year of birth. We also constructed a dataset of cancer cases in siblings of sarcoma subjects to assess familial risk.

Results

In multivariable logistic regression analyses, synovial sarcoma was more frequent in Hispanics compared with non-Hispanic whites [OR, 1.48; 95% confidence interval (CI), 1.06-2.08]. Higher birth weight was a risk factor in Hispanics; each 500 g inc

SUBMITTER: Wiemels JL 

PROVIDER: S-EPMC7605594 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature